Junctions here include SR 237 in Sunnyvale, SR 85 in Mountain View, SR 84 in Menlo Park and Redwood City, SR 92 in San Mateo, and the San Francisco International Airport and I-380 in San Bruno. The portion of the highway from San Jose to South San Francisco is relatively straight and flat, running near the west edge of the San Francisco Bay. The freeway curves north and northwest, bypassing downtown San Jose to the east, and then curves west-northwest, crossing I-880 and State Route 87, the latter just north of the San Jose International Airport. The Bayshore Freeway begins at the Blossom Hill Road interchange on US 101.

Route 101 Bypass, with US 101 using the present State Route 82 ( El Camino Real). Before 1964, it was mostly marked as U.S. The road was originally built as a surface road, the Bayshore Highway, and later upgraded to freeway standards. Within the city of San Francisco, the freeway is also known as James Lick Freeway, named after the California philanthropist. It runs along the west shore of the San Francisco Bay, connecting San Jose with San Francisco. Route 101 (US 101) in the San Francisco Bay Area of the U.S.

Bay area 101 accident